| CAS
NO. |
299-42-3
(Base)
134-72-5 (Sulfate)
|
|
| EINECS
NO. |
206-080-5,
205-154-4 |
| FORMULA |
(C10H15NO)2·H2SO4 |
| MOL
WT. |
428.54 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
(-)-ephedrine sulfate; (-)-ephedrine sulfate (2:1)
(salt); |
|
1-alpha-(1-(methylamino)ethyl)benzyl alcohol sulfate;
1-phenyl-2-methylamino-propanol-1-sulfate; 1-Phenyl-2-(methylamino)propanol
sulfate; L-ephedrine sulfate;
alpha-[1-(methylamino) ethyl] benzenemethanol sulfate (2:1) (salt);
(R-(R',S'))-alpha-(1-(methylamino)ethyl)benzenemethanol sulfate (2:1) (salt);
Bis[[R-(R',S')]-beta-hydroxy-alpha-methylphenethyl)methylammonium] sulphate;
|
| DERIVATION |
|
CLASSIFICATION
|
|
|
PHYSICAL
AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
crystalline powder
|
| MELTING
POINT |
248
- 252 C |
| BOILING
POINT |
|
| SPECIFIC
GRAVITY |
|
| SOLUBILITY
IN WATER |
Soluble
(slightly soluble in EtOH, insoluble in ether) |
| pH |
4.5
- 7 |
| VAPOR
DENSITY |
|
| AUTOIGNITION |
|
| NFPA
RATINGS |
|
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions. Light sensitive. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
| Ephedrine is a sympathomimetic alkaloid originally obtained from species of
Ephedra or prepared synthetically. Its action is similar to that of epinephrine
(a catecholamine hormone secreted by the adrenal medulla and a
neurotransmitter). Its effects, although less powerful, are more prolonged, and
it exerts action when administered orally, whereas epinephrine is effective only
by injection. It is used as muscle relaxants, central nervous system and cardiac
muscle stimulants in combination with others like theophylline. It is used to
prevent hypotension during spinal and infiltration anesthesia; and as a
mydriatic. There are enantiomers in ephedrine structure. (1R,2S)- and
(1S,2R)-enantiomers are designated ephedrine (opposite stereoisomerisms around
the chiral center), whereas (1R,2R)- and (1S,2S)-enantiomers are designated
pseudoephedrine. Commercial ephedrine is (-)-(1R,2S)-ephedrine [also called
(-)-Ephedrine or L-ephedrine], while commercial pseudoephedrine enantiomer is
(1S,2S)-pseudoephedrine [(+)-pseudoephedrine or D-pseudoephedrine].
Pseudoephedrine has less press action and fewer central stimulant effects than
ephedrine. Pseudoephedrine is used as a nasal decongestant and a bronchodilator
to relaxe and open the air passages to the lung to increase the flow of air, and
thus is used in the treatment and/or prevention of symptoms of bronchial asthma
and of reversible bronchospasm associated with chronic bronchitis and emphysema.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
crystalline powder
|
|
IDENTIFICATION
|
passes
test A,B
|
| ASSAY |
98.5.%
- 101.5%
|
|
RELATED
SUBSTANCE
|
Complies
|
|
OPTICAL
ROTATION
|
-30.5°
~ -32.5° (C=5 in water)
|
|
VOLATILES
|
Complies
|
|
SOLVENT
RESIDUE
|
Complies
|
|
HEAVY
METALS
|
20ppm
max
|
| LOSS
ON DRYING |
0.5%
max
|
| TRANSPORTATION |
| PACKING |
25kgs
in fiber drum
|
| HAZARD
CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 22-23 |